Editorial 15(1)

151 - Toxic Alcohols

alcohol poisoning can result in metabolic acidosis, renal failure, blindness, central nervous system (CNS) injury, pulmonary edema, or death. Ethylene glycol is present in antifreeze solutions, deicing solutions, foam stabilizers, and chemical solvents. Methanol is a component of windshield-washing solutions, gas-line antifreeze solutions, solvents, and brake cleaners. Isopropanol is found in r...

147-151 Omur AYDIN

Akalazya, alt özefageal sfinkterin yetersiz gevşemesi ve özefagusta peristaltizmin olmaması durumudur. Nefes darlığı yakınmasıyla kendini gösterebilir. On sekiz yaşındaki erkek hasta öksürük, nefes darlığı ve hırıltı yakınmasıyla hastaneye başvurmuş ve astım tanısı almıştır. Yakınmalarında düzelme olmaması üzerine astım tedavisi giderek artırılmış ve en sonunda kontrolsüz astım ön tanısıyla kli...

149-151 Prevention

Dev111013 151..161

The coordination of cell polarity within the plane of the tissue layer (planar polarity) is crucial for the development of diverse multicellular organisms. Small Rac/Rho-family GTPases and the actin cytoskeleton contribute to planar polarity formation at sites of polarity establishment in animals and plants. Yet, upstream pathways coordinating planar polarity differ strikingly between kingdoms....

Dmd065839 151..161

Efavirenz (EFV) is principally metabolized by CYP2B6 to 8-hydroxyefavirenz (8OH-EFV) and to a lesser extent by CYP2A6 to 7-hydroxyefavirenz (7OH-EFV). So far, most metabolite profile analyses have been restricted to 8OH-EFV, 7OH-EFV, andEFV-N-glucuronide, even though these metabolites represent a minor percentage of EFV metabolites present in vivo.We have performed a quantitative phase I and II...